Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage
نویسندگان
چکیده
Ibuprofen (IBP)- and Tranexamic acid (TXA)-containing tablets are known to swell when stored at high temperatures, but the mechanism of swelling is unknown. In this study, we investigated possible with high-temperature storage. Differential scanning calorimetry (DSC) powder X-ray diffractometry (PXRD) analyses showed that a new complex was formed in swollen tablets, 50 °C for 60 days. Additionally, prepared single crystals IBP TXA, analyzed them using crystal (SCXRD), identify during This revealed salt consisting TXA. The PXRD peak simulated by SCXRD matched tablet after These results suggest close relationship between structures
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ژورنال
عنوان ژورنال: Crystals
سال: 2022
ISSN: ['2073-4352']
DOI: https://doi.org/10.3390/cryst12101420